With the growing popularity of weight loss injections and medications, interest in medical weight loss is at an all-time high. Maybe you’ve seen the headlines or have even heard your family and friends talking. And now you’re asking the same question: What drugs make you skinny?

However, behind this “trend” is a serious health decision that deserves medically accurate information. 

If you’re looking for just that, you’ve come to the right page. In this article, you’ll get a clear look at the science and safety behind today’s most popular prescription weight loss options.

Prescription Medications for Weight Loss: What Actually Works

Prescription medications for weight loss are FDA-approved to treat obesity or serious weight-related conditions, not as “quick fixes.” They work best alongside lifestyle changes like diet, exercise, and behavioral support, and they’re only recommended for people who meet specific medical criteria.

So, what drugs make you skinny? Here’s a breakdown of the most commonly prescribed weight loss drugs.

Orlistat (Xenical/Alli) 

This is one of the few over-the-counter options available in a lower dose (Alli), but it’s also prescribed as Xenical in a stronger form. This medication works in your digestive tract to block some of the fat you eat from being absorbed by your body. Just a caveat: It’s not safe if you have issues absorbing nutrients or conditions like cholestasis.

Phentermine-Topiramate (Qsymia) 

It’s a combination of two medications: phentermine (which suppresses appetite) and topiramate (which is used to treat seizures or migraines). Together, they help reduce hunger and make you feel full sooner. Note that it’s not safe if you have glaucoma, hyperthyroidism, or are taking MAOIs (a type of antidepressant).

Naltrexone-Bupropion (Contrave) 

Naltrexone-bupropion combines two medications used for addiction and depression. It affects the brain’s hunger and reward centers to reduce cravings and help with appetite control. This option is for adults only and isn’t recommended for those with uncontrolled high blood pressure, a history of seizures, or eating disorders like anorexia or bulimia.  

Liraglutide (Saxenda) 

This is an injectable medication that mimics a natural hormone (GLP-1) to regulate appetite and food intake. It's taken daily and is approved for adults and kids aged 12 and up. While it can be very effective, it should be avoided if you or a family member has a history of medullary thyroid cancer or a rare condition called MEN 2.

Semaglutide (Wegovy) 

It works similarly to Saxenda, but it’s given as a weekly injection. It also mimics GLP-1 to help you feel full longer and reduce food intake. Wegovy is approved for adults and children 12 and older, but it's not safe if you have a personal or family history of certain thyroid cancers or MEN 2.

Setmelanotide (IMCIVREE) 

Setmelanotide is a more targeted treatment used only for people with rare, genetically confirmed types of obesity. It works by activating specific brain pathways that control appetite and metabolism. This medication is approved for children 6 and up, but only if they have one of four qualifying genetic disorders. It’s not intended for general weight loss.

Tirzepatide (Zepbound) 

This is one of the newer weight loss drugs and works by mimicking two hormones (GIP and GLP-1) that affect appetite and insulin regulation. It's given as a weekly injection and is approved for adults. Like some others on this list, it shouldn’t be used if there’s a personal or family history of medullary thyroid cancer or MEN 2.

These medications are powerful tools, but they’re also serious medical treatments. They require monitoring, professional guidance, and a clear understanding of your health history. 

What Is Semaglutide and How Does It Support Weight Loss?

Semaglutide was originally developed as a treatment for type 2 diabetes, but people now also use it to help them shed off extra weight. Today, it’s approved under brand names like Ozempic and Wegovy, and has become one of the most talked-about medications for  semaglutide weight loss.

But how does it work?

Semaglutide mimics a natural hormone in your body called GLP-1. This hormone plays a key role in regulating appetite and digestion. By acting like GLP-1 for weight loss, semaglutide helps reduce hunger, slow the rate at which your stomach empties, and increase feelings of fullness after eating.

Semaglutide is typically administered as a weekly injection, making it convenient if you prefer fewer dosing requirements. While Ozempic is primarily prescribed for diabetes, Wegovy is FDA-approved specifically for chronic weight management in individuals with obesity or weight-related conditions.

When paired with a balanced diet and regular physical activity, semaglutide can be a powerful tool for long-term weight loss.

Tirzepatide vs Semaglutide for Weight Loss: Which One Works Better?

When you search about semaglutide, you’ll also often encounter tirzepatide.

Tirzepatide is sold under the brand names Mounjaro (for type 2 diabetes) and Zepbound (for chronic weight management). While both are part of the GLP-1 agonist family, tirzepatide stands out for its dual action: It activates both GLP-1 and GIP receptors (glucose-dependent insulinotropic polypeptide), potentially offering even greater benefit

In clinical trials, people taking semaglutide typically lost between 6 to 10 kg (13.2 to 22 lbs). Those on tirzepatide often experienced more significant results, with average weight loss ranging from 7 to 13 kg (15.4 to 28.6 lbs).

While this suggests tirzepatide may be more effective for weight loss, it can also cause more gastrointestinal side effects. Semaglutide users may also experience similar side effects, including nausea or vomiting, abdominal discomfort, constipation, and fatigue or low energy.

Ultimately, the right choice between tirzepatide vs semaglutide weight loss depends on your health history, weight loss goals, and how your body responds to treatment. 

Tirzepatide may be better for you if:

• You have type 2 diabetes and are also aiming for significant weight loss.
• You’ve already tried other weight loss medications without success.
• You’re comfortable with weekly injections and a higher risk of gastrointestinal side effects for potentially greater results.

Meanwhile, semaglutide may be a better fit if:

• You’re new to GLP-1 medications and want a more established option.
• You have fewer pounds to lose and are looking for consistent, gradual weight loss.
• You prefer a medication with a longer safety track record and slightly milder side effects

Are These Drugs Right for You?

If you’ve been searching “what drugs make you skinny” or looking up “Ozempic shots near me,” it’s important to know these medications aren’t for everyone. 

As mentioned, GLP-1 weight loss drugs like semaglutide and tirzepatide are typically prescribed for individuals with obesity or weight-related health conditions such as type 2 diabetes, high blood pressure, or high cholesterol.

Medical supervision is essential. And it’s not just about safety. It’s about making sure that the treatment is tailored to your body, your health goals, and your lifestyle. These medications work best when combined with a supportive care plan that includes nutrition, movement, and behavior change.

Choosing a trusted provider like RR Wellness and connecting with people who’ve successfully walked this path ensures you receive expert guidance, safe treatment, and a personalized plan for lasting, sustainable results.

Conclusion

Medications like semaglutide and tirzepatide can be powerful tools for weight loss, but they’re not quick fixes. Moreover, they should always be used under medical supervision, alongside nutrition, movement, and mental wellness support.

At RR Wellness Clinic, we’re dedicated to creating personalized, sustainable treatment plans that go beyond the prescription pad. Ready to say hello to a slimmer, healthier you? Get in touch today!